Below is a list of the faculty members who are focused primarily on engineering research. Peter Barker, DPhilProfessor of Radiology, Division of Neuroradiology ResearchThe Johns Hopkins University School of Medicine 600 N Wolfe St, MRI 143C Baltimore, MD 21287 Phone: (410) 955-1740 Fax: (410) 614-253 Email: pbarker2 AT jhmi.edu Dr Barker has been performing research on in vivo magnetic resonance (MR) spectroscopy and imaging for over two decades. His work focuses on both technique development and clinical applications of these methodologies. Dr Barker is also the director responsible for the career development award program on the Johns Hopkins University “ICMIC” program, and has mentored various junior faculty members on NIH K-awards or career development grants (US Army CDMRP). Dr Barker provides training in the areas of neuroradiology, MRI and MRS techniques, computer programming, study design, data analysis, and how to write papers and grants. Emad Boctor, PhDInstructor, Radiology and Associate Professor, Computer ScienceThe Johns Hopkins University School of Medicine JHOC 4253C, 601 N. Caroline St Baltimore, MD 21287 Phone: (443) 287-2975 Email: eboctor AT jhmi.edu Dr. Boctor received B.Sc. Biomedical Engineering from Cairo University, 1995. He received his master and doctoral degree in 2004 and 2006, respectively from Computer Science Department at the Johns Hopkins University. In 2007, Dr. Boctor joined Department of Radiology and Radiological Science at JHU, where he has started a research program in the field of advanced interventional ultrasound imaging. Dr. Boctor’s research focuses on image-guided therapy and surgery; a subject in which he has authored and co-authored over 25 manuscripts, more than five pending patents. Zaver Bhujwalla, PhDProfessor of Radiology, Division of MR ResearchThe Johns Hopkins University School of Medicine Traylor 208, 720 Rutland Ave Baltimore, MD 21205 Phone: (410) 955-9698 Email: zbhujwa1 AT jhmi.edu Dr. Bhujwalla has spent the past decade studying cancer with multinuclear MR, and more recently other imaging modalities. She is Professor of Radiology and Oncology, Director of the JHU ICMIC Program and Director of the Cancer Functional Imaging Resource of the Sidney Kimmel Cancer Center. Much of Dr. Bhujwalla’s work has focused on the application of MR imaging technology to promote the understanding of cancer biology in general and, in particular, to characterize the nature and importance of tumor-specific alterations in cellular metabolism and vascularization. Her major research interests are to understand the role of vascularization, lymphangiogenesis, and the tumor’s physiological environment in breast and prostate cancer invasion and metastasis using imaging techniques. Paul Bottomley, PhDProfessor, RadiologyDirector, Division of Magnetic Resonance Research The Johns Hopkins University School of Medicine 600 N. Wolfe St. Baltimore, MD 21205 Phone: (410) 955-0366 Email: bottoml AT mri.jhu.edu Dr. Bottomley has been working in MRI since 1975, where he was a member of the original team in the Physics Dept at Nottingham that developed the first human MRI scanner. His lab works on optimization of surface MRI detectors to maximize the SNR, including the development of new strip-detectors, as well as tiny catheter-based MRI detectors for internal/intravascular use, and "MRI endoscopy". He developed the original techniques for performing localized NMR spectroscopy, and has ongoing clinical research studies employing phosphorus (31P) to study energy metabolism in humans. Of central interest at the moment following development with Dr Weiss in Cardiology of a method to measure metabolic flux, is the observation of a shortfall in energy supply in patients with heart failure. Jeff Bulte, PhDProfessor of Radiology, Biomedical Engineering,and Chemical & Biomolecular Engineering Director, Cellular Imaging Section, Institute for Cell Engineering The Johns Hopkins University School of Medicin 217 Traylor Bldg, 720 Rutland Ave Baltimore, MD 21205 Phone: (443) 287-0996 or (410)614-2733 Email: jwmbulte AT mri.jhu.edu http://www.hopkinsmedicine.org/profiles/results/directory/profile/3650684/jeff-bulte Dr. Bulte’s clinical development of novel immune and stem cell therapies calls for suitable methods that can follow the fate of cells non-invasively in humans at high resolution. The Bulte lab has pioneered methods to label cells magnetically (using tiny superparamagnetic iron oxide nanoparticles) in order to make them visible by MR imaging. While the lab is doing basic bench-type research, there is a strong interaction with the clinical interventional radiology and oncology groups in order to bring the methodologies into the clinic Eric Frey, PhDProfessor of Rad Medical Physics ImagingThe Johns Hopkins University School of Medicine JHOC 4263, 601 N. Caroline St. Baltimore, MD 21287 Phone: (443) 287-2426 Email: efrey AT jhmi.edu Dr. Frey’s laboratory develops new techniques for single and multiple isotope SPECT imaging and reconstruction for myocardial perfusion, brain neuroreceptor, and radioimmunotherapy treatment planning. He also has developed systems and algorithms for small animal microcomputed tomography using conventional and photon counting detectors. Kristine Glunde, PhDAssistant Professor, Department of Radiology and OncologyThe Johns Hopkins University School of Medicine Traylor 217, 720 Rutland Ave Baltimore, MD 21205 Phone: (410) 614-2705 Email: kglunde AT mri.jhu.edu Dr. Glunde’s research is in the field of multimodal molecular and cellular imaging of breast and prostate cancer. In particular, her laboratory is studying (1) the role of lysosomes and lysosomal trafficking in breast cancer, (2) novel targets in choline phospholipid metabolism, (3) and novel hypoxia-driven signaling pathways in the breast tumor microenvironment. Dr. Glunde’s laboratory has developed novel near-infrared optical imaging agents and demonstrated their feasibility for in vivo optical imaging of breast tumor models. All projects in Dr. Glunde’s laboratory have strong imaging and microscopy components, combined with biochemical, molecular, and cellular methods. These projects study cancer at the cellular and molecular level with a direct impact on the understanding, diagnostic imaging, treatment, and prevention of this disease. Gregory Hager, PhDProfessor, Department of Computer Science, and Mechanical EngineeringThe Johns Hopkins University Whiting School of Engineering NEB 224, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-5521 Email: hager AT cs.jhu.edu http://www.cs.jhu.edu/~hager Dr. Hager's research studies problems related to the modeling, extraction, and exploitation of motion and geometry information in image sequences from many modalities. In light images, his group has pioneered several new methods for visual tracking of targets and methods for image-based control of robots. His group has also developed methods for target tracking in MR sequences and ultrasound. He has also developed methods for video to volume registration for the purposes of surgical navigation and information display. A significant portion of his recent work has been focussed on developing new methods for high accuracy ultrasound elastography and thermal imaging. Daniel Herzka, PhDAssistant Professor, Biomedical EngineeringThe Johns Hopkins University School of Medicine Ross 724, 720 Rutland Ave Baltimore, MD 21205 Phone: (410) 614-252 Email: dherzka1 AT jhmi.edu Dr. Herzka is very active in the research and development of cardiac magnetic resonance imaging (MRI) techniques for the diagnosis and monitoring of cardiovascular disease. Dr. Herzka has previously worked on several applications of fast MRI in both corporate research and academic settings, taking techniques from the design stages, through pre-clinical studies, to application in patients. He developed coronary MRI techniques that have led to improvements in the detection of anomalous coronary trees in patients. Dr. Herzka’s lab is exploring the use of new phase encoding strategies with mathematically irrational and variable phase encode stepping structures. Dr. Herzka is also working closely with physicians in Dr. Halperin’s group on raw-data driven reconstructions that will eliminate scan volume prescription, shifting the burden of motion of compensation from the technologist to intelligent reconstruction algorithms. Jin Kang, PhDProfessor, Electrical and Computer EngineeringThe Johns Hopkins University Whiting School of Engineering Barton Hall 210, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-8186 Email: jkang AT jhu.edu www.ece.jhu.edu/~jkang Jin U. Kang is developing fiber optic sensors and fiber optic imaging devices for various medical and military applications. His lab has demonstrated one of the simplest endoscopic fiber optic optical coherence tomography systems based on common-path Fourier domain set-up. In addition, his lab has demonstrated and developing novel fiber optic confocal imaging, velocity, oxygen saturation, glucose sensing systems based on various optical techniques. His Hopkins collaborators include Drs. Boctor, Hager, Tayor, Handa as well as many colleagues outside Hopkins. Dara Kraitchman, PhDAssociate Professor, RadiologyJohns Hopkins School of Medicine JHOC 4231, 601 N. Caroline St. Baltimore, MD 21287 Phone: (410) 955-4892 E-mail: dkraitc1 AT jhmi.edu Dr. Kraitchman's research interests are concentrated on non-invasive imaging and minimally invasive treatment of cardiovascular disease. She has been actively involved in developing new methods to image myocardial function and perfusion using MRI. Current research interests are aimed at determining the optimal timing and method of administration of mesenchymal stem cells to regenerate infarcted myocardium using non-invasive MR fluoroscopic delivery and imaging. MRI and radiolabeling techniques include novel MR and radiotracer stem cell labeling methods to determine the location, quantity, and biodistribution of stem cells after delivery as well as to noninvasively determine the efficacy of these therapies in acute myocardial infarction and peripheral arterial disease. Recently, the first technique to provide radiopaque labeling of stem cells for x-ray fluoroscopic delivery and CT imaging of stem cell persistence for cardiac and peripheral arterial disease applications has been developed. Albert Lardo, PhDAssociate Professor, Medicine and Biomedical EngineeringThe Johns Hopkins University School of Medicine Ross 1042 / 720 Rutland Ave Baltimore, MD 21205 Phone: (443) 287-7490 Email: alardo AT jhmi.edu Dr. Lardo’s research deals with using high resolution imaging of the heart to optimize diagnosis and delivery of cardiac therapies. Working with clinical colleagues, Dr.Lardo's laboratory has demonstrated a number of novel applications for cardiac computed tomography including the first study to demonstrate that regions of viable myocardium can be visualized by delayed enhanced multi-detector CT, the development of myocardial perfusion imaging by CT and the first combined coronary imaging and myocardial perfusion study in humans. MRI developments include novel methods to assess myocardial dyssynchrony, the first study to use MRI to assess response to bi-ventricular pacing therapy and the development of MRI analysis techniques to phenotype cardiac stem cell therapy. His Hopkins collaborators include Drs. Abraham, Berger, Halperin, Herzka, Kass, Lima, McVeigh, Osman, as well as many colleagues outside Hopkins. Xingde Li, PhDProfessor of Biomedical EngineeringThe Johns Hopkins University School of Medicine Ross 729, 720 Rutland Ave Baltimore, MD 21205 Phone: (410)955-3132 Email: xingde AT jhu.edu Website: http://bit.bme.jhu.edu Dr. Li’s research centers on developing innovative biophotonics and molecular imaging (and potentially integrated therapeutic) technologies, which have great translational potential for early detection and imaged-guided intervention of various pathological conditions such as neoplasia, vulnerable plaques, and impaired wound healing. Dr. Li and his group have developed the first all-fiber-optic flexible scanning endomicroscope that enables intrinsic multiphoton fluorescence and SHG imaging of internal organs in vivo and in real time for the first time, providing structural and biochemical/metabolic information at the cellular and subcellular level. Dr. Li has also developed the first imaging needle (27 Gauge) that enables high-resolution interstitial optical coherence tomography (OCT) imaging and image-guided biopsy of solid tissues/organs which were previously not possible. Recently, Dr. Li and his group have designed and successfully developed fluorescent polymeric nanocomplexes using only FDA approved NIR dye (i.e. Indocyanine Green) and polymers plus anti-cancer drugs, and the low-toxic biofuntionalizable nanocomplexes represent a feasible approach to translate molecular optical imaging and targeted therapy into clinical practice. Christine Lorenz, PhDVisiting Associate Professor, Department of Radiology and Radiological Science and Program Manager, Interventional MR, Siemens Corporate Research, Inc.The Johns Hopkins University School of Medicine Phone: 410-502-5602 Email: christine.lorenz AT siemens.com Dr Lorenz and her group work on methods to facilitate MRI and X-ray-guided procedures for both oncology and cardiovascular disease. In addition to developing a flexible platform for MRI-guided procedures, the group is active in development of methods to make maximum use of real time acquired MR data during interventions, including 4-D modelling to augment acquisition of spatially sparse data, image based physiological modelling, and motion compensation. The group also works on guidance methods for both MR and X-ray procedures, and fusion of MR with X-ray. Dr. Lorenz has 5 engineers from her group on site at Johns Hopkins working side by side with faculty and students on the research systems. Mahadevappa Mahesh, PhDAssociate Professor, RadiologyThe Johns Hopkins University School of Medicine Blalock B179, 600 N. Wolfe St. Baltimore, MD 21287 Phone: (410) 955-5115 Email: mmahesh AT jhmi.edu Dr.
Mahesh’s research interests are in medical imaging, particularly in
areas of multi-detector computed tomography (MDCT), interventional
fluoroscopy and digital mammography. Current research includes patient
dose evaluation during MDCT, radiation dose measurement and optimization
of clinical protocols in MDCT. Elliot R. McVeigh, PhDProfessor and Chair of Biomedical EngineeringThe Johns Hopkins University School of Medicine Suite 720 Ross Building, 720 Rutland Ave Baltimore, MD 21205 The Johns Hopkins University Whiting School of Engineering Clark Hall 316, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 955-3132 or (410) 516-7903 Email: emcveigh AT jhu.edu Assistant: Melanie Mossman mmossman AT jhu.edu or 410-516-7903 Michael Miller, PhDProfessor Biomedical Engineering, Director, Center for Imaging ScienceThe Johns Hopkins University Whiting School of Engineering Clark Hall 301, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-3826 Email: mim AT cis.jhu.edu http://www.cis.jhu.edu The study of human anatomy presents the most difficult challenges to the understudy of typicality and variablity. While Biological shapes are highly structured, they are not rigid. Dr. Miller has been using Grenander's deformable anatomical templates for the representation of the typicality and for the representation of the variablilty. For this, complex anatomical templates (human and macaque brains) are annotated with coordinate systems defined within them. High-dimensional vector fields applied to these coordinate systems carry the templates with all of its geometry into the target. This allows for understanding modulo individual variation. Susumu Mori, PhDProfessor, Department of RadiologyThe Johns Hopkins University School of Medicine Traylor 217, 720 Rutland Ave Baltimore, MD 21205 Phone: (410) 614-2702 Email: susumu AT mri.jhu.edu Dr. Mori is developing new data acquisition and analysis technologies of magnetic resonance imaging to study the brain anatomy. Diffusion tensor imaging and microimaging techniques have been the main focus of the technology development. The new techniques have been applied to various types of brain research including normal brain development and aging as well as diagnosis of brain diseases including Alzheimer's disease, Huntington's disease, and developmental disorders. The technologies have also been applied to high-resolution imaging of developing mouse brains and phenotype characterization. His lab is currently closely collaborating is Dr. Michael Miller for automated MR image analysis. James Pekar, PhDAssociate Professor, RadiologyKennedy Krieger Institute 707 N. Broadway Baltimore, MD 21205 Phone: (443) 923-9510 Email: pekar AT jhu.edu http://mri.kennedykrieger.org Dr. Pekar works on the development and application of this MRI technology. He is a biophysicist who uses a variety of magnetic resonance techniques to study brain physiology and function. Dr. Pekar serves as Manager of the F.M. Kirby Research Center for Functional Brain Imaging, a research resource where imaging scientists and neuroscientists collaborate to study brain function using unique state-of-the-art techniques in a safe comfortable environment, to further develop such techniques, and to provide training and education. Dr. Pekar works with center staff to serve the center's users and to keep the center on the leading edge of technology. Dzung Pham, PhDAssistant Professor, Department of Radiology and Radiological ScienceThe Johns Hopkins University School of Medicine Phipps B100, 600 N. Wolfe St. Baltimore, MD 21287 Phone: (410) 614-3249 Fax: (410) 614-1577 Email: pham AT jhu.edu http://neuroradiology.rad.jhmi.edu/pham.htm Dr. Pham develops novel methods for the analysis and interpretation of medical images. Dr. Pham's laboratory has developed algorithms for performing segmentation of magnetic resonance brain images, reconstruction and analysis of the cerebral cortex, and detection of white matter lesions in Multiple Sclerosis patients. Jerry Prince, PhDProfessor, Department of Electrical and Computer EngineeringThe Johns Hopkins University Whiting School of Engineering Barton Hall 307, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-5192 Email: prince AT jhu.edu http://iacl.ece.jhu.edu/~prince/ Professor Prince conducts research in the Image Analysis and Communications Laboratory and in the Departments of Radiology and Biomedical Engineering, where he holds joint appointments. He and his graduate students are currently involved in several research projects in medical imaging. In one project they are developing methods to estimate cardiac motion using magnetic resonance imaging for ultimate use in the diagnosis of heart disease. In another project they are analyzing magnetic resonance images of the brain to develop a mathematical map of the human cortex. They are also exploring new methods in computed tomography for application in computer integrated surgery. Arman Rahmim, PhDAssistant Professor, Radiology and Electrical and Computer EngineeringAssistant Professor, Radiology and ECE The Johns Hopkins University School of Medicine JHOC 3263, 601 N. Caroline St Baltimore, MD 21287 Phone: (410) 502-8579 Email: arahmim1 AT jhmi.edu Dr. Rahmim directs the Tomographic Image Reconstruction & Analysis Laboratory. His lab pursues interdisciplinary research towards enhanced quantitative image generation and analysis for tomographic medical imaging devices (PET, SPECT, CT) including emphasis on multi-modality imaging (e.g. PET/MRI, PET/CT), including extensive experience and expertise with mathematical, computational and engineering tools to achieve state-of-the-art medical imaging. Dr. Rahmim leads collaborations with researchers in the areas of imaging physics/engineering, mathematics, computer science, radiochemistry, biological modeling and medicine, aiming to develop and validate novel solutions for medical device data acquisition, data correction, image reconstruction and quantification. George Sgouros, PhDProfessor, RadiologyThe Johns Hopkins University School of Medicine 1550 Orleans Street, CRB II 4M.61 Baltimore, MD MD 21231 Phone: (410) 614-0116 Email: gsgouros AT jhmi.edu The Sgouros lab is focused on modeling and dosimetry analysis of radionuclide therapy to support the translation of novel targeted radionuclide therapy strategies to the clinic. The research is divided between laboratory studies and patient-specific dosimetry/radiobiological modeling studies. As an example, in one particular study, the lab is examining alpha-particle emitter (bismuth-213 and actinium-225), targeting of tumor. Intact antibodies and immunoliposomes are being examined as carriers of these isotopes. Jeffrey Siewerdsen, PhDAssociate Professor, Biomedical EngineeringThe Johns Hopkins University School of Medicine Traylor 718, 720 Rutland Ave Baltimore, MD 21205 Phone: (443) 287-6269 Email: jeff.siewerdsen AT jhu.edu Dr. Siewerdsen’s research involves the development of new imaging technologies and the translation of new imaging methods to diagnostic and image-guided procedures. With emphasis in advanced x-ray imaging techniques (including cone-beam CT, tomosynthesis, and dual-energy imaging). Dr. Siewerdsen’s laboratory has offered numerous advances in the field of medical imaging, including: the development of cone-beam CT for image-guided radiation therapy and surgery; design and implementation of systems for ORs of the future; the development of high-performance dual-energy x-ray imaging techniques for diagnostic and image-guided procedures. His research program fosters a highly collaborative, multi-disciplinary environment of medical physicists, engineers, computer scientists, radiologists, radiation oncologists, and surgeons. Katsuyuki Taguchi, PhDAssistant Professor, Department of RadiologyThe Johns Hopkins University School of Medicine JHOC 4253A, 601 N. Caroline St. Phone: (443) 287-2974 Email: ktaguchi AT jhmi.edu Dr. Taguchi has more than 14 years of experience in medical imaging industry. While he was with Toshiba Medical Systems and Toshiba America Medical Systems, working with clinical collaborators, Dr. Taguchi developed and implemented more than 20 novel methods for data acquisition, imaging reconstruction, and data processing of x-ray CT systems which are now widely desiminated. Three major areas of research Dr. Taguchi’s group has been working on are: (1) the fully 4D image reconstruction for cardiac CT with patient dose reduction, (2) energy resolved photon counting CT for improved contrast-to-noise and tissue identification, and (3) quantitative interventional tumor oncology using a C-arm CT system. Russell Taylor, PhDProfessor of Computer Science with joint appointments in Radiology, Surgery, and Mechanical EngineeringThe Johns Hopkins University Whiting School of Engineering NEB 224, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-0740 Email: rht AT jhu.edu Professor Taylor’s research interests span a broad spectrum of topics in computer-integrated interventional medicine, including medical robotics, microsurgery, image-guided percutaneous therapy, surgical navigation, statistical models of bony anatomy, and radiation therapy planning. Ben Tsui, PhDProfessor, RadiologyThe Johns Hopkins University School of Medicine JHOC 4263, 601 N. Caroline St Baltimore, MD 21287 Phone: (443) 287-4025 Email: btsui1 AT jhmi.edu Dr. Tsui’s research interest is in medical imaging, particularly in the area of Single-Photon Computed Emission Tomography (SPECT) and magnetic resonance imaging (MRI). Specific research projects include collimator design, image evaluation, two-dimensional and three-dimensional image reconstruction algorithm development, and quantitative SPECT imaging techniques. He is the head of the Medical Imaging Physics Program within the Department of Radiology at Johns Hopkins Medicine. Peter van Zijl, PhDProfessor, Department of Radiology & Biophysics1217 Traylor Building, 720 Rutland Avenue Baltimore, MD 21205 Phone: (443) 923-9500 Email: pvanzijl AT mri.jhu.edu http://mri.kennedykrieger.org Dr. Van Zijl’s research involves the design of new MRI technology for the study of brain function as well as the understanding of the mechanisms of contrast leading to signal changes in MRI images during functional stimulation. This effort is funded by several grants, one of which is for the F.M. Kirby center to function as a national resource that is dedicated to providing state-of-the-art MRI data acquisition and image processing technology and unique MRI expertise to facilitate the biomedical research of NIH-funded neuroscientists at several institutions in Maryland and throughout the USA. The technological research and development (TRD) proposed in the four core projects of this grant share the general goal of providing neuroscientists with quantitative methodology. Rene Vidal, PhDAssistant Professor, Department of Biomedical EngineeringThe Johns Hopkins University Whiting School of Engineering Clark Hall 302B, 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-7306 Email: rvidal AT jhu.edu http://www.cis.jhu.edu/~rvidal Dr. Vidal explores new methods for analyzing magnetic resonance and diffusion weighted images for medical diagnosis. Working with several collaborators, he has developed segmentation methods for extracting the epicardium in cardiac MR sequences, fiber tracking methods for extracting the Purkinje network in cardiac MR volumes, registration and segmentation methods for diffusion tensor images of the brain, and filtering and interpolation methods for high angular resolution imaging. His Hopkins collaborators include Drs. Cowan, Hager, Terzis, and Trayanova. He also has several collaborations with the industry (Siemens) and other academic institutions (UIUC, UCLA, UC Berkeley, ANU, etc). John Wong, PhDProfessor, Radiation OncologyThe Johns Hopkins University School of Medicine Weinberg 1440, 401 N. Broadway Baltimore, MD 21231 Phone: (410) 502-1459 Email: jwong35 AT jhmi.edu Dr. Wong’s research focus in the clinical area is to optimally match the treatment methodologies to the clinical objectives, taking into account the various sources of technical and clinical uncertainties that exist in the treatment process. In the informatics area, Dr. Wong plays a key role in the multidisciplinary and multi-institutional “OncoSpace” initiative to support data longevity and sharing, and to promote collaborative clinical research and decision support. In the laboratory, Dr. Wong is the principal investigator in the development of a “Small Animal Radiation Research Platform” with advanced imaging and delivery capabilities that allow focal irradiation of laboratory animals to sub-mm accuracy. |
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